Crysophanol Effects on Lipid Peroxidation Levels and Catalase Activity in Mice Hippocampus after Pilocarpine-induced Seizures
نویسندگان
چکیده
Pilocarpine-induced status epilepticus (SE) produces many alterations in central nervous system neurotransmission. Previous work from our laboratory has demonstrated that intraperitoneal administration of pilocarpine 400 mg/kg significantly decreases not only muscarinic M1, M2 and Gabaergic receptors densities, but also decrease acetylcholinesterase (AChE) and increases superoxide dismutase and catalase enzymatic activities in the rat striatum, frontal cortex and hippocampus [1,2]. Recently, it was observed that the acute treatment with 400 mg/kg pilocarpine induces long-lasting alterations in serotonergic and glutamatergic receptors in rat frontal cortex, hippocampus and striatum [3].
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